Ontotarget is an online database that features bio-medical journals that are peer-reviewed at least twice weekly. The Chief editors, Mikhail Blagosklonny and Andrei V. Gudkov have monitored the site since 2010. Scientists or ordinary viewers can enjoy a variety of articles that focus on sub-topics of Oncology including aging, Microbiology, Virology, Immunology and more.
Working towards Better Cancer Treatment
Based on new research published by Oncotarget, there’s a small protein modification that stimulates migratory and invasive properties of prostate cancer cells. This new finding helps scientists understand the movement of the cancer cells from on area to another and can lead to the development of more effective therapies. Listen to an audio podcast of Oncotarget on Itunes.
Metastatic tumors stem from individuals breaking free from a tumor and traveling to an unwanted location. These can further develop into secondary tumors. The prostate cancer cells mentioned in the study mainly travels through epithelial-to-mesenchymal transition (EMT) activated by growth factor known as TGFB (transforming growth factor beta). However, unwanted proteins such as Snail1 gets activated in the process, creating complications in the body. Listen to Oncotarget podcast on Player.FM.
— Oncotarget (@OncotargetJrnl) December 12, 2017
Researchers from two Swedish Universities were able to determine the following information about the role and modification of Snail1:
– Sumoylation, the process of modifying the amino acids (building blocks) of Snail1, can reduce its effects and make cancer cells more invasive.
– Snail1 induces TGFB signaling and EMT in prostate cancer.
– In patients with prostate cancer, they have elevated levels of Snail1.
Although it is uncertain whether Snail1 is the main cause of prostate cancer, sumoylating the protein can combat the cancer and possibly breast cancer tumors.
Learn more: https://www.ncbi.nlm.nih.gov/pmc/journals/1558/